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Can you donate blood or plasma if you have herpes?

Short answer

Genital herpes is not an American Red Cross deferral if you are feeling healthy and well and you meet all the other eligibility rules. At the NIH Clinical Center you cannot donate while herpes or cold-sore lesions are active, and you can once they are dry and almost healed. Of the plasma companies checked here, only KEDPLASMA names genital herpes: you can still donate if you have had or been exposed to certain STDs, genital herpes included, with a three-month delay after full recovery and completion of treatment. CSL Plasma, BioLife, Grifols Plasma, Octapharma, and Interstate Blood Bank do not mention herpes, so ask the center you will use.

Checked September 28, 2026 · Sources: Red Cross, NIH, FDA, AABB, plasma centers, listed at the end · This site is run by an employee of the company that owns PositiveSingles. Why that matters

Can you donate blood if you have herpes?

At the American Red Cross, genital herpes is not a cause for deferral if you are feeling healthy and well and you meet all the other eligibility rules. The NIH Clinical Center says You cannot donate with herpes or a cold sore when the lesions are active.

You can donate if the lesions are dry and almost healed. The American Red Cross eligibility page does not mention cold sores. The genital-herpes sentence does not cover a sore on your mouth. AABB names cold sores, as gingivostomatitis and orolabial ulcers, and it does not say you can donate with one.

Although all blood banks are required to follow general federal regulations, specific criteria may vary, depending on each blood bank's internal policies. The FDA says you must be in good health and free of infections that can be transmitted through a blood transfusion. Not feeling well on the day of donation can defer you. Syphilis or gonorrhea is a separate rule: wait 3 months after treatment.

Can you donate plasma if you have herpes?

KEDPLASMA says you can still donate if you have had or been exposed to certain STDs, and genital herpes is on that list. In these cases, there is a three-month delay after full recovery and completion of treatment.

A later paragraph names only chlamydia and gonorrhea. Those are temporary disqualifiers, and they will not prevent you from donating later. Genital herpes is not in that paragraph.

CSL Plasma, BioLife, Grifols Plasma, Octapharma Plasma, and Interstate Blood Bank do not mention herpes, cold sores, or herpes antivirals, so ask the center you will use. KEDPLASMA reviews your current medications at the pre-screening exam and does not name herpes on that requirements page.

What each organization says
OrganizationHerpesAntiviralsPaid?
American Red CrossNot a cause for deferral if you are feeling healthy and well and meet all other eligibility rulesNot named. In almost all cases medications will not disqualify you. Eligibility depends on why the drug was prescribed. No source here says valacyclovir, acyclovir, or famciclovir is allowedNot stated
NIH Clinical CenterYou cannot donate while herpes or cold-sore lesions are active. You can donate if they are dry and almost healedNot namedNot stated
KEDPLASMAOn the list of STDs you can still donate after if you have had or been exposed to them. Three-month delay after full recovery and completion of treatmentNot named. Current medications are reviewed at the examNo dollar amount quoted here
CSL PlasmaNot mentioned. Ask a Medical Staff AssociateNot mentioned. Ask a Medical Staff AssociatePayment on a reloadable debit card, based on your weight that day. Up to $100 on the first donation and up to $800 in the first month as a new donor. Varies by location and is subject to change
BioLife PlasmaNot mentioned. Ask the centerNot mentioned. Ask the centerCan put some extra money in your pocket. No dollar amount
Grifols PlasmaNot mentioned. Ask the centerNot mentioned. Ask the centerCompensation on a prepaid debit card after each donation. Rates vary by location
Octapharma PlasmaNot mentioned. Ask the centerNot mentioned. Ask the centerPrepaid debit card within 24 hours of a successful donation. Up to $750 with bonuses in the first 35 days. May vary by location and change without notice
Interstate Blood BankNot mentioned. Ask the center. Whole blood, not the Grifols Plasma pageNot mentioned. Ask the centerCompensates whole-blood donors for their time

Can you donate while taking valacyclovir or acyclovir?

No source says you may donate while taking valacyclovir, acyclovir, or famciclovir. The American Red Cross and the NIH blood bank do not name those drugs.

In almost all cases, medications will not disqualify you as a blood donor. Your eligibility will be based on the reason the medication was prescribed, and donation is usually permitted when the condition is under control and you are healthy. Acyclovir, valacyclovir, and famciclovir are not named on the American Red Cross eligibility page or on its medication-deferral list.

AABB names acyclovir, famciclovir, and valacyclovir as drugs used to treat herpes virus infections. It does not say whether you may donate while taking them.

These waits are for antibiotics, not for valacyclovir, acyclovir, or famciclovir, and antibiotics are a different kind of drug. The American Red Cross says to wait until you have finished oral antibiotics for a bacterial or viral infection, and the NIH says you can donate 24 hours after the last dose if you have no further signs of infection. BioLife says you should be able to come back after antibiotics for an infection once you have finished and the symptoms are gone, typically 2 to 7 days after the prescription ends. If your prescription never comes up, ask the center you will use, and CSL says to take medication, condition, and procedure questions to a Medical Staff Associate.

Do blood banks and plasma centers test for herpes?

Herpes simplex is not on the FDA's list of infections that blood is tested for, or in the 21 CFR 630.3 list. AABB says No FDA-licensed blood donor screening test exists. KEDPLASMA screens donors for STDs and does not put genital herpes on the list of STDs that prevent donation.

After you donate, blood establishments must test that unit for relevant transfusion-transmitted infections or, for certain infections, implement pathogen reduction technology when appropriate. These infections include hepatitis B, hepatitis C, HIV types 1 and 2, HTLV types I and II, syphilis, West Nile virus, Babesia, and Chagas disease. 21 CFR 630.3 names the same group without Babesia, and adds CJD, variant CJD, and malaria. AABB's sheet includes herpes simplex viruses 1 and 2, and no specific donor question is in use.

Source plasma donations have to be tested for HIV, hepatitis B, and hepatitis C. A syphilis test for those donors is required on a sample under the plasmapheresis rule. Those donations do not have to be tested for HTLV, West Nile virus, or Chagas disease.

Interstate Blood Bank says Each donation is thoroughly tested for various infectious agents including Hepatitis B, Hepatitis C, HIV and Syphilis. Herpes simplex is not in that sentence. KEDPLASMA screens every donor for STDs and does a physical exam before donation. The STDs it names as preventing donation include HIV, hepatitis B and C, HTLV, and syphilis, and genital herpes is not among them. What a herpes test can show is in the herpes test guide.

When should you wait to donate?

Wait if you do not feel well on the day of donation. At the NIH Clinical Center you cannot donate while herpes or cold-sore lesions are active, and you can once they are dry and almost healed.

If you have a fever or an active infection, the American Red Cross says to wait until the infection has resolved completely before donating blood. It does not name herpes.

You are not eligible if you are not in good health, or if the center finds anything that could make the donation less safe for you or for the blood itself. The phlebotomy site, where the needle goes into your arm, must be free of infection, inflammation, and lesions, not a herpes sore elsewhere on your body. For a cold or the flu, the NIH says You can donate once you have been symptom-free for 48 hours. BioLife says a cold or the flu can leave you run-down and dehydrated, so reschedule until you feel healthy and no longer show signs of illness, and come back when you are feeling better.

Octapharma says it is best to postpone until you are fully recovered, because colds, flu, COVID-19, or infections can temporarily disqualify you and a cold or the flu can mean a short-term deferral. KEDPLASMA's three-month delay comes after full recovery and completion of treatment for the STD list that includes genital herpes, and the American Red Cross does not set that three-month wait when you are feeling healthy and well and meet all the other eligibility rules. AABB says No FDA Guidance or AABB Standard exists. If you have symptomatic primary genital or orolabial HSV, you may not feel well on donation day and would often be deferred, and if you report recurrent HSV the practice varies by center.

The outbreak guide covers what an outbreak does. For what the diagnosis changes, and what it does not, see is herpes a big deal.

Sources

  • American Red Cross, Blood Donor Eligibility Criteria. Genital herpes is not a cause for deferral if you feel healthy and well and meet the other rules. Syphilis or gonorrhea: wait 3 months after treatment. Wait if you do not feel well on the day of donation. Wait if you have a fever or a productive cough. If you have a fever or an active infection, wait until it has resolved completely. Skin over the vein must not be affected. In almost all cases medications will not disqualify you. Cold sores, acyclovir, valacyclovir, and famciclovir are not named. Read September 28, 2026.
  • NIH Clinical Center, Can I Donate If...?. No donation with herpes or a cold sore while lesions are active. You can donate if lesions are dry and almost healed. Specific criteria may vary by blood bank. Cold or flu: symptom-free for 48 hours. Antibiotics: 24 hours after the last dose if you have no further signs of infection. The three herpes antivirals are not named. Read September 28, 2026.
  • FDA, Have You Given Blood Lately?. Content current as of 01/11/2024. Be free of infections that can be transmitted by transfusion. Not feeling well can defer you. The named test list runs from hepatitis B through Chagas disease. Herpes simplex is not on it. Read September 28, 2026.
  • eCFR, 21 CFR 630.3, 610.40, 640.65, 630.10, and 606.121. up to date as of 9/24/2026. Named relevant infections run from HIV through malaria. Whole blood is tested for HIV, HBV, and HCV, plus HTLV, syphilis, West Nile virus, and Chagas disease. Source plasma is tested for HIV, HBV, and HCV; not for HTLV, West Nile virus, or Chagas disease; syphilis there is the plasmapheresis sample. The phlebotomy needle site must be free of infection, inflammation, and lesions. A paid donor receives monetary payment. A volunteer donor does not. Read September 28, 2026.
  • AABB, Herpes viruses (other than CMV, EBV, and HHV-8). Includes HSV-1 and HSV-2 and names cold sores. No FDA-licensed donor screening test. No specific donor question. No FDA guidance or AABB standard, so no number of days. The deferral bullet is about people with symptomatic primary genital or orolabial HSV: they may not feel well on the day of donation and would often be deferred. Recurrent HSV, if the donor reports it, is handled differently at each center. Acyclovir, famciclovir, and valacyclovir appear as treatment. Read September 28, 2026.
  • Plasma Protein Therapeutics Association. People are compensated for plasma, and each facility sets its own rates. A collection page says donors may be compensated. The FAQ compares a modest stipend with gift cards and tokens for blood donors. Read September 28, 2026.
  • CSL Plasma, FAQ and rewards. Payment on a reloadable debit card, based on weight that day. New donors: up to $100 on the first donation and up to $800 in the first month as a new donor, varying by location and subject to change. Herpes is not mentioned. Medication questions go to a Medical Staff Associate. Read September 28, 2026.
  • BioLife Plasma, checklist, deferrals, and FAQ. Checklist dated Feb 3, 2026: reschedule if unwell. Deferrals dated Feb 27, 2026: come back when you feel better. Antibiotics for an infection: after you finish, once symptoms are gone, typically 2-7 days. The FAQ mentions extra money and no dollar amount. Herpes is not mentioned. Read September 28, 2026.
  • Grifols Plasma, FAQ and compensation. Compensated on a prepaid debit card. Rates vary by location. The appointment lasts around an hour. At least 110 lbs, generally good health, ages 18 to 69. Herpes is not mentioned. Read September 28, 2026.
  • Octapharma Plasma, new donors, homepage, and deferrals. Prepaid debit card within 24 hours of a successful donation. Up to $750 with bonuses in the first 35 days. The amount may vary by location and change without notice. Postpone if unwell. Colds, flu, COVID-19, or infections can disqualify you for a time. Herpes is not mentioned. Read September 28, 2026.
  • KEDPLASMA, STDs and requirements. STD page dated October 9, 2024. Genital herpes is on the list you can still donate after, with a three-month delay after full recovery and completion of treatment. A later paragraph names chlamydia and gonorrhea only. Preventing STDs: HIV, hepatitis B and C, HTLV, and syphilis. Medications are reviewed. No dollar amount is quoted here. Read September 28, 2026.
  • Interstate Blood Bank, Donor FAQs. Whole blood. Donors are compensated for their time. Each donation is tested for various infectious agents, including hepatitis B, hepatitis C, HIV, and syphilis. Herpes simplex is not in that sentence. Read September 28, 2026.